DNA VACCINES 2012 - December 4-7, 2012 - Loes Coronado Bay Resort, San Diego, CA

2012 Agenda

Tuesday, December 4

5:00 PM - 8:00 PM

Wednesday, December 5

7:30 AM
Registration Opens

7:30 AM - 8:45 AM
Continental Breakfast in Exhibit/Poster Area

8:45 AM - 9:00 AM
Welcome to DNA Vaccines 2012
David B. Weiner, PhD
Professor, University of Pennsylvania

The Future of Malaria Vaccines

Chairs: Ashley Birkett & Niranjan Sardesai

9:00 AM - 9:30 AM
Development of Vaccines to Support Malaria Elimination
Ashley Birkett, PhD
Director, Research and Development, PATH Malaria Vaccine Initiative (MVI)

9:30 AM - 10:00 AM
Robust CD8+ T-Cell-Dependent IFN-Gamma Responses Against Restricted Domains on P. Falciparum Antigens Induced by a DNA- Prime-Adenovector Boost Vaccine Regimen are Associated with Protection Against Sporozoite Challenge
Martha Sedegah, PhD
Senior Scientist & Director, Clinical Immunology Malaria Program, Navy Component, U. S. Military Malaria Vaccine Program

10:00 AM - 10:30 AM
From the Bench to the Clinic: Development of Viral Vector-Based Blood-Stage Malaria Vaccines
Sumi Biswas, DPhil
Group Leader/Post Doctoral Scientist, The Jenner Institute

10:30 AM - 11:00 AM
Coffee/Networking Breaking in Exhibit/Poster Area

Frontiers in Vaccine Research

Chairs: Matti Sällberg & Martha Sedegah

11:00 AM - 11:30 AM
Therapeutic Indications for DNA Vaccines
Tony Ford Hutchinson, PhD
President, Ford-Hutchinson Consulting Ltd

11:30 AM - 12:00 PM
What is the Role of Therapeutic Vaccination in the Era of Directly Acting Antivirals in the Therapy of Hepatitis C
Matti Sällberg, PhD
Board Member & Consultant, Tripep AB
Professor, Karolinska Institutet

12:00 PM - 12:30 PM
Tuberculosis Vaccines
David Hokey, PhD
Director of Immunology, Aeras

12:30 PM - 1:45 PM
Lunch in Exhibit/Poster Area

Cutting Edge RNA Technologies

Chairs: Peter Liljeström & Andrew Geall

1:45 PM - 2:10 PM
DNA/RNA Replicon Vaccines
Peter Liljeström, PhD
Professor of Infectious Disease Control, Karolinska Institutet

2:10 PM - 2:35 PM
Non-Viral Delivery of Self-Amplifying RNA Vaccines
Andrew Geall, PhD
RNA Vaccine Platform Technology Leader, Novartis Vaccines & Diagnostics

2:35 PM - 3:00 PM
Development of Therapeutic and Prophylactic Vaccines
Karl-Josef Kallen, MD, PhD
Chief Scientific & Chief Medical Officer, CureVac GmbH

3:00 PM - 3:30 PM
Coffee/Networking Breaking in Exhibit/Poster Area

Abstract Session

Chairs: Anne De Groot & Amir Khan

3:30 PM - 3:45 PM
A Multi-agent Encephalitic Alphavirus DNA Vaccine Delivered by Electroporation Elicits Protective Immunity against Aerosol Challenge with Eastern and Western Equine Encephalitis Viruses in Nonhuman Primates
Drew Hannaman - Vice President, Ichor Medical Systems, Inc.

3:45 PM - 4:00 PM
Inducing Potent Humoral and Cellular Responses to Multiple Sporozoite and Liver-Stage Malaria Antigens Using pDNA
Bernadette Ferraro, PhD, MPH
Postdoctoral Fellow, University of Pennsylvania

4:00 PM - 4:15 PM
Development of a Novel DNA Vaccine Strategy for Prevention of Clostridium Difficile Infection
Michele A. Kutzler, PhD
Assistant Professor, Drexel University College of Medicine

4:15 PM - 4:30 PM
NF-ĸB Activation Mediates Tumor-Specific CTL Responses Elicited by DNA Vaccines
Maarten Ligtenberg
PhD Candidate, Karolinska Institutet

4:30 PM - 5:30 PM
Plenary Roundtable I - Chairs: John Sterling & David Weiner Development and Commercialization of Novel Vaccines
Ashley Birkett
Tony Ford Hutchinson
Niranjan Sardesai
Jeffrey Ulmer

5:30 PM - 7:00 PM
Cocktail Reception in Exhibit/Poster Area

Thursday, December 6

7:30 AM
Registration Opens

7:30 AM - 9:00 AM
Continental Breakfast in Exhibit/Poster Area

Future Immunogens for Vaccination

Chairs: Jeffrey Ulmer & Allain Rolland

9:00 AM - 9:30 AM
Technologies for the Discovery and Development of New Vaccines
Jeffrey Ulmer, PhD
Global Head, External Research, Novartis Vaccines & Diagnostics

9:30 AM - 10:00 AM
Intra- and Inter-Cellular Signaling Pathways for DNA Vaccination
Ken Ishii, MD, PhD
Project Leader, Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation

10:00 AM - 10:30 AM
Allovectin® Systemic Immunotherapy for Metastatic Melanoma - Phase 3 Study and Pre-licensure Activities
Alain Rolland, PharmD, PhD
Executive Vice President, Vical Incorporated

10:30 AM - 11:00 AM
Coffee/Networking Break in Exhibit/Poster Area

Cancer Immune Therapy

Chairs: Richard Heller & Christian Ottensmeier

11:00 AM - 11:30 AM
Targeted Cancer Immune Therapy
Christian Ottensmeier, MD, PhD
Professor, University of Southampton

11:30 AM - 12:00 PM
Gene Electrotransfer for the Enhanced Delivery of Immunomodulating Agents
Richard Heller, PhD
Director and Professor, Old Dominion University

12:00 PM - 12:30 PM
Clinical Studies of Melanoma Therapy
Adil Daud, MD
Clinical Professor of Medicine and Dermatology, Director, Melanoma Program, University of California, San Francisco

12:30 PM - 1:40 PM
Lunch in Exhibit/Poster Area

Technologies and Approaches for Difficult Pathogens

Chairs: Drew Hannaman & Bin Wang

1:40 PM - 2:00 PM
The Co-Immunization Strategy Induces Tolerogenic Responses Against Autoimmune Diseases--Its Potential Applications and Mechanisms Behind
Bin Wang, PhD
Professor, Fudan University Shanghai Medical College

2:00 PM - 2:20 PM
Assessment of Clinical Feasibility For Electroporation Mediated DNA Vaccination in Infectious Disease Applications
Drew Hannaman
Vice President, Ichor Medical Systems, Inc

2:20 PM - 2:40 PM
Electroporation-Mediated Genetic Vaccination for Antigen Mapping: Application to Plasmodium Falciparum VAR2CSA Protein
Daniel Scherman, PhD
Exceptional Class Director of the Centre National de la Recherche Scientifique

2:40 PM - 3:05 PM
Modulating T Cell Immunity to Target Cancer: Establishing Effective Responses to Tumor Antigens That are Over-Expressed Self-Proteins
Philip Greenberg, MD
Professor of Medicine and Immunology, University of Washington

3:05 PM - 3:30 PM
Coffee/Networking Break in Exhibit/Poster Area


Chairs: Adel Mahmoud & Dennis Burton

3:30 PM - 4:00 PM
Dilemma of Immunogen Discovery!
Adel Mahmoud, MD, PhD
Lecturer with Rank of Professor in Molecular Biology and Public Policy, Woodrow Wilson School, Princeton

4:00 PM - 4:30 PM
A Blueprint for HIV Vaccine Discovery
Dennis Burton, PhD
Professor, Immunology & Microbial Science, The Scripps Research Institute

4:30 PM - 5:00 PM
Vaccination with HIV DNA and Plasmid IL-12 Delivered via Electroporation Elicits Robust Cellular Immune Responses
Spyros Kalams, MD
Associate Professor of Medicine, Vanderbilt University School of Medicine

5:00 PM - 5:40 PM
Plotkin Lecture - Immunoprophylaxis by Gene Transfer:  Shortcut to an HIV Vaccine
Introduction of speaker by David B. Weiner, PhD
Philip Johnson, MD
Chief Scientific Officer and Executive Vice President, The Children's Hospital of Philadelphia

Gala - Awards and Roundtable Discussion- The Future of Nucleic Acid Vaccine Technologies - Chairs Margaret Liu & Niranjan Sardesai
Robert Bernard
Philip Greenberg
Joseph Kim
Hy Levitsky
Adel Mahmoud

Friday, December 7

Registration Opens

Continental Breakfast in Exhibit/Poster Area

Industry Session

Chairs: Michael Chambers & George Pavlakis

8:30 AM - 8:45 AM
Essential Elements of DNA Vaccine Production for Human Clinical Trials
Dorothy Peterson
Vice President of Operations, VGXI, Inc.

8:45 AM - 9:00 AM
Purification of Plasmid DNA on Monolithic Chromatographic Columns
Nika Lendero Krajnc, PhD
Chief Research & Development Officer, BIA Separations d.o.o.

9:00 AM - 9:15 AM
Heterologous DNA-Prime/Peptide-Boost Vaccination with Cross-Conserved H1N1 Influenza CD4+ T-cell Epitopes Reduces Viral Load in HLA Transgenic Mice
Leonard Moise, PhD
Scientific Director Vaccine Research, EpiVax, Inc.

9:15 AM - 9:30 AM
Expression Kinetic Profiles of Electroporation Enhanced DNA Vaccination Targeted to Different Dermal Compartments
Kate Broderick PhD
Director, Research and Development, Inovio Pharmaceuticals, Inc

Frontiers in Cancer Immune Therapy

Chairs: Hy Levitsky & Mark Bagarazzi

9:30 AM - 10:00 AM
Therapeutic Immunity-from Vaccination to Disease Eradication
Hy Levitsky, MD
Head of Cancer Immunology Experimental Medicine, Roche

10:00 AM - 10:30 AM
Immune Therapies for HPV Disease
Cornelia Trimble, MD
Associate Professor, Johns Hopkins School of Medicine

10:30 AM - 11:00 AM
Coffee/Networking Break in Exhibit/Poster Area

Cancer Frontiers

Chairs: Cornelia Trimble & Mark Selby

11:00 AM - 11:30 AM
Blocking Negative Regulators to Enhance Anti-Tumor Responses
Mark Selby, PhD
Director, Bristol Meyers Squibb

11:30 AM - 12:00 PM
Immunotherapy Directed Against HPV 16/18 Generates Potent Th1 and Cytotoxic Cellular Immune Responses
Mark Bagarazzi, MD
Chief Medical Officer, Inovio Pharmaceuticals, Inc.

12:00 PM - 12:20 PM
DNA-based Immunization Against Endosialin Compromises Tumor Perfusion and Growth without Affecting Normal Angiogenesis
Andrea Facciabene, MD, PhD
Research Assistant Professor,University of Pennsylvania

12:20 PM - 1:45 PM
Lunch in Exhibit/Poster Area

HIV Technology

Chairs: Shan Lu & Britta Wahren

1:45 PM - 2:05 PM
DNA Vaccination 20 Years Later - Elicitation of High Quality Antibody Responses
Shan Lu, PhD
Professor of Medicine, University of Massachusetts Medical School

2:05 PM - 2:25 PM
Feasibilities and Present Results on Childhood HIV Immunization
Britta Wahren, MD, PhD
Professor, Karolinska Institutet

2:25 PM - 2:45 PM
Therapeutic DNA Vaccination Induces Durable Functional Cure in SIV-Infected Rhesus Macaques
Deborah Fuller, PhD
Associate Professor, Department of Microbiology, Core Scientist, Washington National Primate Research Center, University of Washington

2:45 PM - 3:05 PM
Comparison of Systemic and Mucosal Responses after DNA and Protein Co-Immunization
Barbara Felber, PhD
Principal Investigator, Frederick National Laboratory for Cancer Research

3:05 PM - 3:30 PM
Coffee/Networking Break in Exhibit/Poster Area

Abstract Session

Chairs: Barbara Felber & Deborah Fuller

3:30 PM - 3:45 PM
Increasing Breadth and Altering the Immundominance Hierarchy of HIV-1 Gag by a DNA Vaccine Expressing Conserved Elements of p24gag in Immunized Macaques
George Pavlakis, MD, PhD
Principal Investigator, Human Retrovirus Section, Vaccine Branch, Center for Cancer Research

3:45 PM - 4:00 PM
In Vivo Monitoring of Immune Response in Preclinical Trials of Genetic Vaccines
Maria Isaguliants, PhD
Senior Researcher, Karolinska Institutet

4:00 PM - 4:15 PM
Examining the Safety, Tolerability and Immunogenicity of a DNA-based Influenza Vaccine in the Elderly; A Phase I Study
Trina Racine, PhD
Post-doctoral fellow, National Microbiology Laboratory, Public Health Agency of Canada

4:15 PM - 4:30 PM
Multivalent Particle-Mediated DNA Vaccine Against Seasonal and Pandemic Influenza Viruses Elicit Strong Antibody Responses in Non-Human Primates
Merika Treants
Graduate Student

4:30 PM - 4:45 PM
Characterization of Influenza Virus-Specific T lymphocyte Responses Induced by Gene Gun-Delivered Multivalent DNA Vaccine
Jolie Leonard, PhD
Postdoctoral Fellow, University of Washington

4:45 PM - 5:00 PM
Conference Summary and Closing Remarks
David B. Weiner, PhD